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Rams vs. Seahawks NFL TNF odds, previews, picks, and predictions

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Thursday Night Football in Week 16 of the NFL season is the biggest game in the NFC West between the Los Angeles Rams and the Seattle Seahawks. Both teams are 11-3. Whoever wins will not only take first place in the division but will also – for now – be the top seed in the conference.

Let’s get into my Rams vs. Seahawks.

Los Angeles Rams vs. Seattle Seahawks odds

Money line: Rams +108 / Seahawks -126
Spread: Rams +1.5 (-110) / Seahawks -1.5 (-110)
Total: Over 42.5 (-110) / Under 42.5 (-110)

Los Angeles Rams vs. Seattle Seahawks best bet #1: Under 42.5 (-110)

It has been raining all day every day in Seattle. What’s new?!?! The rain may move away during the game, but the pitch will be a disaster and the conditions will often not be conducive to attacking football. It’s not the only reason why the bottom looks good. Both defenses are stellar. Seattle is No. 2 in the league in scoring defense, No. 4 in total defense, No. 3 against the run, No. 2 in yards per carry allowed, No. 7 against the pass, No. Los Angeles is fourth in scoring, ninth against the run, eighth in yards per pass attempt allowed and sixth in takeaways.

The two arch-rivals already faced off in Week 11 (in LA-friendly conditions) — combining for 40 points in a 21-19 home win. The Rams intercepted Seahawks QB Sam Darnold four times in that contest. Despite getting the win, Los Angeles mustered just 249 yards of total offense, including just 130 passing yards. Wide receiver Davante Adams suffered a hamstring injury last week in the loss to Detroit and is questionable this time; left tackle Alaric Jackson (ankle) is questionable, too. For the Seahawks, Charles Cross (hamstring) is also questionable. The total is already down from 44.5, but it’s still playable even at this number.

Los Angeles Rams vs. Seattle Seahawks best player prop bet: Kyren Williams Over 55.5 rushing yards (-112)

For the same reasons, moving the ball through the air could be difficult for the visitors on Thursday – even for a quarterback of Matthew Stafford’s caliber. First, conditions will likely be difficult when you pass. Second, the Seahawks defense is very good against the pass. Coach Mike Macdonald’s team is allowing just 191.4 passing yards per contest on 6.0 yards per attempt. Seattle is solid against the run, too, but not completely dominant.

Williams should be able to get open against the ‘Hawks, as he did in Week 11. The former Notre Dame standout rushed for 91 yards and a TD despite receiving just 12 rushing attempts. Seattle controlled time of possession for nearly 38 minutes to Los Angeles’ 22. That’s why Williams only got 12 possessions; he can be expected to see more action in this second head-to-head contest. He’s already surpassed the 1,000-yard mark in 2025 and has rushed for at least 72 yards in six of his past seven outings.

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