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Giants vs. Patriots NFL MNF Odds, previews, picks, and predictions

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Monday night football in Week 13 of the 2025 NFL season is a long-standing rivalry, as the New York fans visit the New England Patriots. Only New England looks like the Super Bowl Guntender of decades past. They currently lead the AFC with a 10-2 record, while New York is the exact opposite at 2-10.

Let’s dive into the predictions of the vs.

New York Giants vs New England Patriots Adds

Money Line: Giants +280 / Patriots -360
Spread: Giants +7 (-110) / Patriots -7 (-110)
Total: Over 46.5 (-110) / Under 46.5 (-110)

New York Giants vs New England Patriots Best Bet #1: Patriots -7 (-110)

The gap between these two groups is as big as their mirror image records suggest. The patriots rode the cave of nine children to victory; The Giants have lost six in a row. There’s no reason to think those trends won’t continue on Monday night. All has not gone well in New York since the short injection with rookie quarterback Jewson Dart taking over from Russell Wilson. DART has faced all kinds of concerns, star receiver Malik Nabers is out for the year with a torn aclle, head coach Brian Daboll was fired a few weeks ago, and defensive coordinator Shane Bowen was fired last week. After all that, what’s left of the Giants is a terrible team on both sides of the ball. DART is back after losing the last two games, but he can’t be trusted because of his physical condition and his back-up threat – or lack thereof.

New England, on the other hand, is a well-oiled machine in every aspect of the game. Head Coach Mike Vrabel and Quarterback Drake Maye have this franchise in great shape for both the present and the future. Vrabel is the current Coach of the Year Frontrunner and Meye in the MVP discussion as the league leader in passing yards (3,130) to go along with the NFL’s most touchdowns. Defensively, the Patriots rank highest in EPA in total EPA and 2nd in Run Defense (87.7 Yards per game). It’s hard to see this game competing – especially in New England.

New York Giants vs New England Patriots Player Player Player Bet: Treveyon Henderson over 60.5 rushing yards (-110)

This is Henderson’s flagship location. The Giants have an interim head coach and defensive coordinator, and they’ve been terrible against the run even with Daboll’s closer. They are dead last in the league in both rushing yards per game allowed (157.2) and yards per game allowed (5.9). No other team averaged more than 5.3 yards per attempt.

Henderson should be able to take full advantage. The Ohio State product is on a hot streak right now, scoring five touchdowns in the last three contests and running all over Tampa Bay for 147 yards in Week 10. RB2 RHAMONDRE Stevenson has only had one good game this series and had just six carries in Week 12. Their difference in touchdowns.

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