Monday night football in week 12 of the 2025 NFL season is a showdown in the NFC between the Carolina Panthers and the San Francisco 49ers. It could end up being an important contest for the wild card position, as Carolina enters with a 6-5 record and San Francisco is 7-4.
Let’s dive into My Panthers vs. 49ers Predictions.
Carolina Panthers vs. San Francisco 49ers Engds
Money Line: Panthers +310 / 49ers -395
Spread: Panthers +7.5 (-115) / 49ers -7.5 (-105)
Total: Over 49.5 (-110) / Under 49.5 (-110)
Carolina Panthers vs. San Francisco 49ers best bet #1: over 49.5 (-110)
Brock Purdy is back with San Francisco. The OTT-WALTED quarterback returned in week 11 and looked as good as good, leading the 49ers to Arizona while completing 19 attempts for 200 yards with three touchdowns and no interceptions. With the Niners offense healthier than it has been all year, more success should be expected on Monday night. Top wide picks Picky Pealeall and junior Jennings are back, as is tight end George Kittle.
The news isn’t good for San Francisco on the other side of the ball. With Nick Bosa and Fred Warner out for the year, the 49ers defense has crumbled. At the EPA, San Fran is No. 31 in the NFL in defensive efficiency. It has allowed 114 points in the last four games, too. Carolina’s offense may not be anything special, but it should be playing with some confidence after Bryce Jr. walked in an overtime win at Atlanta in Week 11 (448 yards three TDS). Now he faces the Niners defense last in defense (254.5 Wards per game) and No. 25 in yards per pass attempt allowed (7.6). Entering week 12, no team has thrown more than the 49ers. They are 7-3-1 o / you. Over is also 11-4 in past 15 road games
Carolina Panthers vs San Francisco 49ers Best Player Player Bet: Christian McCaffrey over 42.5 ReceVing Yards (-115)
McCaffrey is the most impressive RB in the NFL. The Stanford standout has already made 74 receptions on 96 targets for 732 yards and five TDs. He was productive when Mac Jones was QB for the 49ers, but he has a much better and broader rapport with Purdy. In three games with Purdy under center so far in 2025, McCaffrey has 67 receiving yards and two receiving scores.
The former Panthers has passed that number 42.5 in 10 of 11 games this year and his lowest output is 40 yards. In fact, he has surpassed the 50-yard mark nine times and the 60-yard mark. More of the same should continue against a Panthers defense that is allowing 212.8 passing yards per contest and 7.2 yards per attempt (11th in the league). Carolina offered a four-day hold on opposing RBs.
